POLYPS REGENERATE, WE DON’T: HYDRA’S CELLULAR AND MOLECULAR REGENERATION SYSTEM

AUTHOR – Y. О. KOROLOV, CANDIDATE OF LAW SCIENCE, DOCTORAL STUDENT OF THE DEPARTMENT OF LAW, PRIVATE HIGHER EDUCATIONAL ESTABLISHMENT, «EUROPEAN UNIVERSITY», SPACE INTERNATIONAL COMPANY, INVIDUAL BUSINESS Y.O.KOROLOV. EMAIL: SOAHCIT@GMAIL.COM. ORCID ID: 0009-0000-2037-3419

BEST CITATION – Y. О. KOROLOV, POLYPS REGENERATE, WE DON’T: HYDRA’S CELLULAR AND MOLECULAR REGENERATION SYSTEM, ILE MULTIDISCIPLINARY JOURNAL, 4 (2) OF 2025, PG. 167-174, APIS – 3920-0007 | ISSN – 2583-7230

Abstract

The basis of Hydra’s tremendous regenerative capacity is the “stemness” of its epithelium, which continuously undergoes self-renewing mitotic divisions and has the ability to follow the pathways of differentiation and youthfulness of the organism. Now, new molecular tools have shed light on the molecular processes that control these pathways and may create rejuvenation. In this review, I discuss how a modular tissue architecture may enable continuous cell turnover in Hydra. I also describe the discovery and regulation of factors that control the transition from self-renewing epithelial stem cells to differentiated cells.

Keywords: RNA-binding domains; RNA-binding proteins; machine learning; protein-protein interaction network.